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Innovative Research/Human sL-Selectin ELISA Kit/IRKTAH5232/1 Ea

Innovative Research/Human sL-Selectin ELISA Kit/IRKTAH5232/1 Ea
  • Innovative Research/Human sL-Selectin ELISA Kit/IRKTAH5232/1 Ea
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ProductDescription

HumansL-SelectinELISAKit-1Kit(96Wells)
OurHumansL-SelectinELISAKitisasandwichELISAintendedforthequantitativedeterminationofhumanL-Selectinincellculturesupernates,serumandplasma(heparin,EDTA,citrate).

L-selectin,alsoknownasCD62L,isacelladhesionmoleculefoundonleukocytes.Itbelongstotheselectinfamilyofproteins,whichrecognizesialylatedcarbohydrategroups.ItiscleavedbyADAM17.SELL(L-selectin)isacellsurfacecomponentthatisamemberofafamilyofadhesion/homingreceptorswhichplayimportantrolesinleukocyte-endothelialcellinteractions.Themoleculeiscomposedofmultipledomains:onehomologoustolectins,onetoepidermalgrowthfactor,andtwototheconsensusrepeatunitsfoundinC3/C4bindingproteins.1L-selectinactsasa"homingreceptor"forleukocytestoentersecondarylymphoidtissuesviahighendothelialvenules.LigandspresentonendothelialcellswillbindtoleukocyteexpressingL-selectin,slowingleukocytetraffickingthroughtheblood,andfacilitatingentryintoasecondarylymphoidorganatthatpoint2.

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